Journal article
Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice
CH Leo, JLM Ou, ES Ong, CX Qin, RH Ritchie, LJ Parry, HH Ng
Biomedicine and Pharmacotherapy | Published : 2023
Abstract
Background: The peptide hormone relaxin has potent anti-fibrotic and anti-inflammatory properties in various organs, including the kidneys. However, the protective effects of relaxin in the context of diabetic kidney complications remain controversial. Here, we aimed to evaluate the effects of relaxin treatment on key markers of kidney fibrosis, oxidative stress, and inflammation and their subsequent impact on bile acid metabolism in the streptozotocin-induced diabetes mouse model. Methods and results: Male mice were randomly allocated to placebo-treated control, placebo-treated diabetes or relaxin-treated diabetes groups (0.5 mg/kg/d, final 2 weeks of diabetes). After 12 weeks of diabetes o..
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Awarded by Australian Research Council
Funding Acknowledgements
This research was partially supported by an Australian Research Council Linkage Grant (LP110200543) to LJP and supported in part by the Victorian Government's Operational Infrastructure Support Program. CHL was a recipient of the Faculty Early Career Award (Ministry of Education, Singapore) . CXQ is supported by the Australian Heart Foundation Future Leader Fellowship (102787) . RHR was supported by the Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship (ID1059660) . The sponsors have no role in the study design, collection, analysis, and interpretation of data, or writing of the report and in the decision to submit the article for publication. The authors thank Mr. Joseph Tan for his technical support and assistance in this study.